Wethersfield is a town in Hartford County, Connecticut, USA, immediately south of Hartford along the Connecticut River. Many records from colonial times spell the name "Weathersfield", while Native Americans called it "Pyquag". The towns motto is "Ye Most Auncient Towne in Connecticut", and its population was 26,668 in the 2010 census. The town is primarily served by Interstate 91. The neighborhood known as Old Wethersfield is the states largest historic district, spanning two square miles and 1,100 buildings, dating back to the 17th, 18th and 19th centuries.